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Patrick A. Holt

Patrick A. Holt

Patrick A. Holt, M.D., Ph.D.

Hand and Wrist, Elbow

Dr. Holt specializes in Hand, Wrist and Elbow nerve decompression surgery, trauma, and complex reconstruction. He is one of only a few fellowship-trained hand surgeons on the Lower Eastern Shore and sees patients in Salisbury, Berlin and Seaford. Having grown up in Annapolis, Maryland, he is thrilled to serve the local Maryland, Virginia and Delaware communities. His primary practice goal is to help restore patient form and function using the latest advances in Hand and Microvascular Surgery.

Dr. Holt completed a fellowship in Hand and Microvascular Surgery at Duke University and his residency in Orthopaedic Surgery at the University of Utah. He attended medical school at the University of Louisville where he obtained dual MD-PhD degrees specializing in Medicine as well as Biochemistry and Molecular Biology. Dr. Holt received an undergraduate degree in Biomedical Engineering and a MS graduate degree in Biotechnology specializing in Bioinformatics from The Johns Hopkins University.

Dr. Holt is an active member in the American Academy of Orthopaedic Surgeons (AAOS), American Society for Surgery of the Hand (ASSH), American Association for Hand Surgery (AAHS) and the Maryland Orthopaedic Association (MOA).

Education and Accomplishments

Curriculum Vitae

Board Certifications

  • American Board of Orthopaedic Surgery, 2020


Hand and Microvascular Surgery Duke University, Durham, NC 2017-2018


Department of Orthopaedic Surgery University of Utah, Salt Lake City, UT 2012-2017

Medical School

Doctor of Medicine (M.D.) University of Louisville, Louisville, KY Completed 2012 Doctor of Philosophy (Ph.D.) University of Louisville, Louisville, KY Completed 2010


Master of Science – Biotechnology The Johns Hopkins University Completed 2002


Bachelor of Science – Biomechanical Engineering The Johns Hopkins University Completed 2000


  • State of Maryland
  • State of Delaware
  • State of North Carolina
  • State of Utah

Professional Organizations

  • The American Society for Surgery of the Hand (ASSH)
  • The American Association for Hand Surgery (AAHS)


Tyser, A. Holt, P.A., Randall, R: Diagnostic Evaluation of Upper Extremity Masses and Tumors.
Orthopedics 2017,(5):1-7

Goodwin, M.: Jacobson, L.G.: Holt, P.A.: Rothberg, D.L.:Jones, K.B. Knot Tying 101: Hip to be Square | Orthopaedic Knowledge Online Journal | 2015, 13, (9): 2

Snyder, R.D.; Holt, P.A.; Maguire, J.M.; Trent, J.O. Evidence for the contribution of non-covalent steroid interactions between DNA and topoisomerase in the genotoxicity of steroids.
Drug Chem Toxicol | 2014, 1-8

Snyder, R.D.; Holt, P.A.; Maguire, J.M.; Trent, J.O. Prediction of noncovalent Drug/DNA interaction using computational docking models: Studies with over 1350 launched drugs.
Environ Mol Mutagen | 2013, 1-15

Le, H.T.; Miller, M.C.; Buscaglia, R.; Dean, W.L.; Holt, P.A.; Chaires, J.B.; Trent, J.O., Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4.
Org Biomol Chem | 2012, 10, (47), 9393-404

Holt, P. A.; Buscaglia, R.; Trent, J. O.; Chaires, J. B., A Discovery Funnel for Nucleic Acid Binding Drug Candidates. Drug Development Research | 2011, 72, 1-9

Miller, M.C.; Le, H.T.; Dean, W.L.; Holt, P. A.; Chaires, J.B.; Trent, J.O., Polymorphism and resolution of oncogene promoter quadruplex-forming sequences. Org Biomol Chem
2011, 9,(22), 7633-7

Cunningham, A.; Qamar, S.; Carrasquer, A.; Holt, P. A..; Maguire, J.; Cunningham, S.; Trent, J., Mammary Carcinogen-Protein Binding Potentials: Novel and Biologically Relevant Structure-Activity Relationship Model Descriptors. SAR QSAR Environ Res | 2010, 21, (5-6), 463-79

Holt, P. A.; Ragazzon, P.; Strekowski, L.; Chaires, J. B.; Trent, J. O., Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform.
Nucleic Acids Res | 2009, 37, (4), 1280-7

Dailey, M. M.; Hait, C.; Holt, P. A.; Maguire, J. M.; Meier, J. B.; Miller, M. C.; Petraccone, L.; Trent, J. O., Structure-based drug design: from nucleic acid to membrane protein targets.
Exp Mol Pathol | 2009, 86, (3), 141-50

Holt, P. A.; Chaires, J. B.; Trent, J. O., Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex. J Chem Inf Model | 2008, 48, (8), 1602-15

Wei Y.; Chen J.; Rosas G.; Tompkins D.; Holt P.; Rao R. Phenotypic Screening Of Mutations In Pmr1, the Yeast Secretory Pathway Ca2+/Mn2+-ATPase, Reveals Residues Critical for Ion Selectivity and Transport. J Biol Chem | 2000, 275, (31), 23927-32

Awards and Honors

Chief Administrative Resident, The University of Utah, 2016-2017

$50,000- OREF Young Investigator Grant, The University of Utah, 2013

$15,000- The Sherman S. Coleman Incentive Seed Grant Program Award- The University of Utah, 2013

The Biochemistry and Molecular Biology Physician/Scientist Award- The University of Louisville, 2012

The Dr. Norvin Green Memorial Prize- The University of Louisville, 2012


Neurovascular Camera Research Polarization Research The University of Utah, Washington University, 2014-2018

Ph.D. Research- Department of Biochemistry and Molecular Biology, University of Louisville

Patient Education Center