Patrick A. Holt, MD PhD

Patrick A. Holt

Orthopaedic Surgeon
Hand, Wrist, and Elbow Surgery

Dr. Holt is one of a few fellowship-trained hand surgeons on the Lower Eastern Shore.  Hand surgery is a holistic venture, merging orthopaedics, neurology, microsurgery and plastic surgery. Dr. Holt received an undergraduate degree in biomechanical engineering and graduate degree in biotechnology from The Johns Hopkins University prior to attending Medical School at University of Louisville. Dr. Holt also obtained a Doctor of Philosophy from the University of Louisville in addition to his medical degree. Dr. Holt completed his residency in orthopaedic surgery at University of Utah and a fellowship in Hand and Microvascular Surgery at Duke University.

Outside of his career as a Hand and Microvascular Surgeon, he enjoys mountain climbing and hiking with his wife and two sons, Henry and Ethan.

Curriculum Vitae

Board Certification
Board Eligible

Fellowship
Hand and Microvascular Surgery
Duke University
Durham, NC
2017-2018

Residency
Department of Orthopaedic Surgery
University of Utah
Salt Lake City, UT
2012-2017

Medical School
Doctor of Medicine (M.D.)
University of Louisville
Louisville, KY
Completed 2012

Doctor of Philosophy (Ph.D.)
University of Louisville
Louisville, KY
Completed 2010

Graduate
Master of Science – Biotechnology
The Johns Hopkins University
Completed 2002

Undergraduate
Bachelor of Science – Biomechanical Engineering
The Johns Hopkins University
Completed 2000

Licenses:
State of Maryland
State of Delaware
State of North Carolina
State of Utah

Professional Organizations
The American Society for Surgery of the Hand (ASSH)
The American Association for Hand Surgery (AAHS)

Grants and Awards
Chief Administrative Resident, The University of Utah, 2016-2017

$50,000- OREF Young Investigator Grant, The University of Utah, 2013

$15,000- The Sherman S. Coleman Incentive Seed Grant Program Award- The University of Utah, 2013

The Biochemistry and Molecular Biology Physician/Scientist Award- The University of Louisville, 2012

The Dr. Norvin Green Memorial Prize- The University of Louisville, 2012

Research
Neurovascular Camera Research Polarization Research The University of Utah, Washington University, 2014-2018

Ph.D. Research- Department of Biochemistry and Molecular Biology, University of Louisville
2007-2010

Publications
Tyser, A. Holt, P.A., Randall, R: Diagnostic Evaluation of Upper Extremity Masses and Tumors.
Orthopedics 2017,(5):1-7

Goodwin, M.: Jacobson, L.G.: Holt, P.A.: Rothberg, D.L.:Jones, K.B. Knot Tying 101: Hip to be Square | Orthopaedic Knowledge Online Journal | 2015, 13, (9): 2

Snyder, R.D.; Holt, P.A.; Maguire, J.M.; Trent, J.O. Evidence for the contribution of non-covalent steroid interactions between DNA and topoisomerase in the genotoxicity of steroids.
Drug Chem Toxicol | 2014, 1-8

Snyder, R.D.; Holt, P.A.; Maguire, J.M.; Trent, J.O. Prediction of noncovalent Drug/DNA interaction using computational docking models: Studies with over 1350 launched drugs.
Environ Mol Mutagen | 2013, 1-15

Le, H.T.; Miller, M.C.; Buscaglia, R.; Dean, W.L.; Holt, P.A.; Chaires, J.B.; Trent, J.O., Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4.
Org Biomol Chem | 2012, 10, (47), 9393-404

Holt, P. A.; Buscaglia, R.; Trent, J. O.; Chaires, J. B., A Discovery Funnel for Nucleic Acid Binding Drug Candidates. Drug Development Research | 2011, 72, 1-9

Miller, M.C.; Le, H.T.; Dean, W.L.; Holt, P. A.; Chaires, J.B.; Trent, J.O., Polymorphism and resolution of oncogene promoter quadruplex-forming sequences. Org Biomol Chem
2011, 9,(22), 7633-7

Cunningham, A.; Qamar, S.; Carrasquer, A.; Holt, P. A..; Maguire, J.; Cunningham, S.; Trent, J., Mammary Carcinogen-Protein Binding Potentials: Novel and Biologically Relevant Structure-Activity Relationship Model Descriptors. SAR QSAR Environ Res | 2010, 21, (5-6), 463-79

Holt, P. A.; Ragazzon, P.; Strekowski, L.; Chaires, J. B.; Trent, J. O., Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform.
Nucleic Acids Res | 2009, 37, (4), 1280-7

Dailey, M. M.; Hait, C.; Holt, P. A.; Maguire, J. M.; Meier, J. B.; Miller, M. C.; Petraccone, L.; Trent, J. O., Structure-based drug design: from nucleic acid to membrane protein targets.
Exp Mol Pathol | 2009, 86, (3), 141-50

Holt, P. A.; Chaires, J. B.; Trent, J. O., Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex. J Chem Inf Model | 2008, 48, (8), 1602-15

Wei Y.; Chen J.; Rosas G.; Tompkins D.; Holt P.; Rao R. Phenotypic Screening Of Mutations In Pmr1, the Yeast Secretory Pathway Ca2+/Mn2+-ATPase, Reveals Residues Critical for Ion Selectivity and Transport. J Biol Chem | 2000, 275, (31), 23927-32

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